Mercuric chloride: Target Organs and Levels of Evidence for TR-408
Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Mercuric chloride
7487-94-7 | 07/10/1991 | Gavage
R: 0,2.5,5, M: 0,5,10 MG/KG/60 PER GROUP | International Research & Development Corp. |
Levels of Evidence
Male Rats: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50
|
| May Have Been Related | - Thyroid Gland Follicular Cell:
ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50
|
| Non-Neoplastic Lesions | - KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA
- FORESTOMACH: PAPILLARY HYPERPLASIA
- NASAL CAVITY: INFLAMMATION
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 0/49 2/50
|
| Non-Neoplastic Lesions | - FORESTOMACH: PAPILLARY HYPERPLASIA
- NASAL CAVITY: INFLAMMATION
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 0/50 2/49 OR ADENOCARCINOMA 0/50 0/50 1/49
|
| Non-Neoplastic Lesions | - KIDNEY: NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA
|
