Target Organs and Levels of Evidence for TR-408
Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Mercuric chloride
7487-94-7 |
07/10/1991 |
Gavage
R: 0,2.5,5, M: 0,5,10 MG/KG/60 PER GROUP |
International Research & Development Corp. |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50
|
| May Have Been Related |
- Thyroid Gland Follicular Cell: ADENOMA 1/50 4/50 0/50 OR CARCINOMA 1/50 2/50 6/50
|
| Non-Neoplastic Lesions |
- KIDNEY: NEPHROPATHY; TUBULAR HYPERPLASIA
- FORESTOMACH: PAPILLARY HYPERPLASIA
- NASAL CAVITY: INFLAMMATION
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/49 2/50
|
| Non-Neoplastic Lesions |
- FORESTOMACH: PAPILLARY HYPERPLASIA
- NASAL CAVITY: INFLAMMATION
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 0/50 2/49 OR ADENOCARCINOMA 0/50 0/50 1/49
|
| Non-Neoplastic Lesions |
- KIDNEY: NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: NEPHROPATHY
- NASAL CAVITY: OLFACTORY EPITHELIAL METAPLASIA
|
