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Target Organs and Levels of Evidence for TR-410

Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Naphthalene 91-20-3	03/11/1991	Inhalation 0,10 (75 mice/sex/group),30 (150 mice/sex/group) PPM	Man Tech, Inc.

Levels of Evidence

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	NASAL CAVITY: INFLAMMATION, CHRONIC; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: INFLAMMATION, CHRONIC

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/68 2/64 28/134
Non-Neoplastic Lesions	NASAL CAVITY: INFLAMMATION, CHRONIC; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: INFLAMMATION, CHRONIC