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Target Organs and Levels of Evidence for TR-411

Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
C.I. Pigment red 23 6471-49-4	03/11/1991	Dosed-Feed R&M: 0, 10000, 25000, 50000 PPM (60 PER GROUP)	Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA 0/50 0/48 0/50 2/50 OR CARCINOMA 0/50 0/48 1/50 1/50 COMBINED 0/50 0/48 1/50 3/50
Non-Neoplastic Lesions	KIDNEY: RENAL TUBULE, HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
Other Considerations	HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 22/50 10/50 4/50

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Other Considerations	HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 7/50 3/50 3/50

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA