Target Organs and Levels of Evidence for TR-411
Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
C.I. Pigment red 23 6471-49-4 |
03/11/1991 |
Dosed-Feed R&M: 0, 10000, 25000, 50000 PPM (60 PER GROUP) |
Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 0/48 0/50 2/50 OR CARCINOMA 0/50 0/48 1/50 1/50 COMBINED 0/50 0/48 1/50 3/50
|
Non-Neoplastic Lesions |
- KIDNEY: RENAL TUBULE, HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
|
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 22/50 10/50 4/50
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 7/50 3/50 3/50
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA
|