Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/10471

C.I. Pigment Red 23: Target Organs and Levels of Evidence for TR-411

Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		Peer Review DateRoute/Exposure LevelsStudy Laboratory
C.I. Pigment red 23
6471-49-4		03/11/1991Dosed-Feed
R&M: 0, 10000, 25000, 50000 PPM (60 PER GROUP)		Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/48 0/50 2/50 OR CARCINOMA 0/50 0/48 1/50 1/50 COMBINED 0/50 0/48 1/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: RENAL TUBULE, HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 22/50 10/50 4/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 7/50 3/50 3/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA