C.I. Pigment Red 23: Target Organs and Levels of Evidence for TR-411
Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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C.I. Pigment red 23 6471-49-4 | 03/11/1991 | Dosed-Feed R&M: 0, 10000, 25000, 50000 PPM (60 PER GROUP) | Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Kidney Tubular Cell:
ADENOMA 0/50 0/48 0/50 2/50 OR CARCINOMA 0/50 0/48 1/50 1/50 COMBINED 0/50 0/48 1/50 3/50
|
Non-Neoplastic Lesions | - KIDNEY: RENAL TUBULE, HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
|
Other Considerations | - HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 22/50 10/50 4/50
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
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Other Considerations | - HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 7/50 3/50 3/50
|
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA
|
Female Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - FORESTOMACH: HYPERKERATOSIS; EPITHELIUM, HYPERPLASIA
|