Target Organs and Levels of Evidence for TR-414
Toxicology and Carcinogenesis Studies of Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Pentachloroanisole
1825-21-4 |
11/21/1991 |
Gavage
MR: 0, 10, 20, OR 40 FR&M: 0, 20, OR 40 MG/KG |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 12/50 17/50 23/50 15/48 OR MALIGNANT PHEOCHROMOCYTOMA 3/50 2/50 4/50 0/48 COMBINED 15/50 18/50 25/50 15/48
|
| Non-Neoplastic Lesions |
- KIDNEY: PIGMENTATION, RENAL TUBULE EPITHELIUM
- NASAL CAVITY: PIGMENTATION, OLFACTORY EPITHELIUM
- LIVER: PIGMENTATION, HEPATOCYTES
- PANCREAS: FOCAL HYPERPLASIA
|
| Other Considerations |
- PANCREAS: 12/49 1/49 1/49 0/50
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 3/50 7/50 9/50
|
| Non-Neoplastic Lesions |
- ADRENAL GLAND: HYPERPLASIA
- KIDNEY: PIGMENTATION, RENAL TUBULE EPITHELIUM
- NASAL CAVITY: PIGMENTATION, OLFACTORY EPITHELIUM
- LIVER: PIGMENTATION, HEPATOCYTES
|
| Other Considerations |
- MAMMARY GLAND: FIBROADENOMA 19/50 10/50 7/50
- UTERUS/CERVIX: STROMAL POLYP 13/50 13/50 7/50; STROMAL SARCOMA 2/50 1/50 0/50
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 0/50 4/50 7/48
- Vascular System (Liver): HEMANGIOSARCOMA 2/50 8/50 10/50
|
| Non-Neoplastic Lesions |
- ADRENAL GLAND: HYPERPLASIA; HYPERTROPHY
- LIVER: CYTOLOGIC ALTERATION; KUPFFER CELL PIGMENTATION; BILIARY TRACT HYPERPLASIA; SUBACUTE INFLAMMATION; MIXED CELL FOCI
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LIVER: CYTOLOGIC ALTERATION; KUPFFER CELL PIGMENTATION; BILIARY TRACT HYPERPLASIA; SUBACUTE INFLAMMATION
|
