Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/10479

Target Organs and Levels of Evidence for TR-415

Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Polysorbate 80 (glycol)
9005-65-6		 07/10/1991 Dosed-Feed
0,2.5,5.0%/20 PER GROUP		 Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 21/50 19/50 29/50
Non-Neoplastic Lesions
  • ADRENAL GLAND: HYPERPLASIA
Female Rats: No Evidence
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION; ULCER