Polysorbate 80 (glycol): Target Organs and Levels of Evidence for TR-415
Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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Polysorbate 80 (glycol) 9005-65-6 | 07/10/1991 | Dosed-Feed 0,2.5,5.0%/20 PER GROUP | Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Adrenal Gland Medulla:
PHEOCHROMOCYTOMA 21/50 19/50 29/50
|
Non-Neoplastic Lesions | - ADRENAL GLAND: HYPERPLASIA
|
Female Rats: No Evidence
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION
|
Female Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION; ULCER
|