Target Organs and Levels of Evidence for TR-415
Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Polysorbate 80 (glycol)
9005-65-6 |
07/10/1991 |
Dosed-Feed
0,2.5,5.0%/20 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 21/50 19/50 29/50
|
| Non-Neoplastic Lesions |
- ADRENAL GLAND: HYPERPLASIA
|
Female Rats: No Evidence
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS HYPERPLASIA; INFLAMMATION; ULCER
|
