Target Organs and Levels of Evidence for TR-416
Toxicology and Carcinogenesis Studies of o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
o-Nitroanisole 91-23-6 |
11/21/1991 |
Dosed-Feed (CORE STUDY) R: 0, 222, 666, 2000 PPM M: 0, 666, 2000, 6000 PPM (STOP STUDY) R: 0, 6000, 18000 PPM; 50/GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50
- Urinary Bladder: (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60
- Intestines: (STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60
- Kidney Transitional Cell: PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60
|
May Have Been Related |
- Kidney Tubular Cell: ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49
- Forestomach: SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50
|
Non-Neoplastic Lesions |
- FORESTOMACH: FOCAL HYPERPLASIA; ULCERS
- KIDNEY: TUBULAR FOCAL HYPERPLASIA; NEPHROPATHY; (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA
- URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50
- Urinary Bladder: (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60
- Intestines: (STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60
- Kidney Transitional Cell: (STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60
|
May Have Been Related |
- Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50
|
Non-Neoplastic Lesions |
- URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA
- FORESTOMACH: FOCAL HYPERPLASIA
- KIDNEY: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50
|
Female Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 14/50 2/50 36/50 18/50
|