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Target Organs and Levels of Evidence for TR-419

Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
HC yellow 4 59820-43-8	07/09/1991	Dosed-Feed MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Pituitary Gland: ADENOMA 17/45 20/49 28/49
Non-Neoplastic Lesions	PITUITARY GLAND: HYPERPLASIA

Female Rats: No Evidence

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA