HC Yellow 4: Target Organs and Levels of Evidence for TR-419
Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
HC yellow 4
59820-43-8 | 07/09/1991 | Dosed-Feed
MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Pituitary Gland:
ADENOMA 17/45 20/49 28/49
|
| Non-Neoplastic Lesions | - PITUITARY GLAND: HYPERPLASIA
|
Female Rats: No Evidence
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA
|
