Target Organs and Levels of Evidence for TR-419
Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
HC yellow 4
59820-43-8 |
07/09/1991 |
Dosed-Feed
MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Pituitary Gland: ADENOMA 17/45 20/49 28/49
|
| Non-Neoplastic Lesions |
- PITUITARY GLAND: HYPERPLASIA
|
Female Rats: No Evidence
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- THYROID GLAND: PIGMENTATION; FOLLICULAR CELL HYPERPLASIA
|
