Target Organs and Levels of Evidence for TR-421
Toxicology and Carcinogenesis Studies of Talc (CASRN 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Talc 14807-96-6 |
06/23/1992 |
Inhalation R & M: 0, 6, AND 18 MG OF TALC/M3 OF ATMOSPHERE |
Lovelace Biomedical & Environmental Research Institute |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 25/49 30/48 36/47 OR MALIGNANT PHEOCHROMOCYTOMA 3/49 3/48 7/47 COMBINED 26/49 32/48 37/47
|
Non-Neoplastic Lesions |
- LUNG: GRANULOMATOUS INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR EPITHELIAL HYPERPLASIA; PERIBRONCHIAL HYPERPLASIA; ALVEOLAR SQUAMOUS METAPLASIA
- LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA; (MEDIASTINAL) HISTIOCYTIC HYPERPLASIA
- NASAL CAVITY: RESPIRATORY EPITHELIAL HYPERPLASIA; CYTOPLASMIC ALTERATION
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 0/48 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 5/50 COMBINED 1/50 0/48 13/50
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/48 14/47 18/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 10/49 COMBINED 13/48 14/47 23/49
|
Non-Neoplastic Lesions |
- LUNG: GRANULOMATOUS INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR EPITHELIAL HYPERPLASIA; PERIBRONCHIAL HYPERPLASIA; CYST; ALVEOLAR SQUAMOUS METAPLASIA
- LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA; (MEDIASTINAL) HISTIOCYTIC HYPERPLASIA
- NASAL CAVITY: CYTOPLASMIC ALTERATION
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: CHRONIC INFLAMMATION; MACROPHAGE HYPERPLASIA
- LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA
- NASAL CAVITY: CYTOPLASMIC ALTERATION
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: CHRONIC INFLAMMATION; MACROPHAGE HYPERPLASIA
- LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA
- NASAL CAVITY: CYTOPLASMIC ALTERATION
|