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Target Organs and Levels of Evidence for TR-421

Toxicology and Carcinogenesis Studies of Talc (CASRN 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Talc
14807-96-6		 06/23/1992 Inhalation
R & M: 0, 6, AND 18 MG OF TALC/M3 OF ATMOSPHERE		 Lovelace Biomedical & Environmental Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 25/49 30/48 36/47 OR MALIGNANT PHEOCHROMOCYTOMA 3/49 3/48 7/47 COMBINED 26/49 32/48 37/47
Non-Neoplastic Lesions
  • LUNG: GRANULOMATOUS INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR EPITHELIAL HYPERPLASIA; PERIBRONCHIAL HYPERPLASIA; ALVEOLAR SQUAMOUS METAPLASIA
  • LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA; (MEDIASTINAL) HISTIOCYTIC HYPERPLASIA
  • NASAL CAVITY: RESPIRATORY EPITHELIAL HYPERPLASIA; CYTOPLASMIC ALTERATION
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 0/48 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 5/50 COMBINED 1/50 0/48 13/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/48 14/47 18/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 10/49 COMBINED 13/48 14/47 23/49
Non-Neoplastic Lesions
  • LUNG: GRANULOMATOUS INFLAMMATION; INTERSTITIAL FIBROSIS; ALVEOLAR EPITHELIAL HYPERPLASIA; PERIBRONCHIAL HYPERPLASIA; CYST; ALVEOLAR SQUAMOUS METAPLASIA
  • LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA; (MEDIASTINAL) HISTIOCYTIC HYPERPLASIA
  • NASAL CAVITY: CYTOPLASMIC ALTERATION
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; MACROPHAGE HYPERPLASIA
  • LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA
  • NASAL CAVITY: CYTOPLASMIC ALTERATION
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; MACROPHAGE HYPERPLASIA
  • LYMPH NODE: (BRONCHIAL) HISTIOCYTIC HYPERPLASIA
  • NASAL CAVITY: CYTOPLASMIC ALTERATION