Target Organs and Levels of Evidence for TR-422
Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Coumarin 91-64-5 |
Gavage R: 0,25,400, M: 0,30,150 MG/KG/5 PER GROUP |
International Research & Development Corp. |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Coumarin 91-64-5 |
06/23/1992 | Gavage R: 0,25,50,100; M: 0,50,100,200 MG/KG/60 & 70 PER GROUP RESPECTIVELY |
American Biogenics Corp (Bioassay Systems) |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Male Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|