Target Organs and Levels of Evidence for TR-423
Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
3,4-Dihydrocoumarin 119-84-6 |
06/23/1992 | Gavage R: 0,150,300,600, M: 0,200,400,800 MG/KG/50 PER GROUP |
American Biogenics Corp (Bioassay Systems) |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
May Have Been Related |
|
Non-Neoplastic Lesions |
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Non-Neoplastic Lesions |
|
Male Mice: No Evidence
Female Mice: Some Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
3,4-Dihydrocoumarin 119-84-6 |
Gavage R: 0,75,1200, M: 0,100,1600 MG/KG/10 PER GROUP |
International Research & Development Corp. |