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Target Organs and Levels of Evidence for TR-424

Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
o-Benzyl-p-chlorophenol 120-32-1		Gavage 0,30,480 MG/KG/10 PER GROUP	Battelle Columbus Laboratory

Levels of Evidence: None

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
o-Benzyl-p-chlorophenol 120-32-1	12/01/1992	Gavage MR: 0,30,60,120, FR: 0,60,120,240, M: 0,120,240,480 MG/KG/50 PER GROUP	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: INCREASED SEVERITY OF NEPHROPATHY PARATHYROID GLAND: HYPERPLASIA BONE: CRANIAL FIBROUS OSTEODYSTROPHY; FEMUR FIBROUS OSTEODYSTROPHY GLANDULAR STOMACH: MINERALIZATION

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Transitional Cell: CARCINOMA 0/50 0/50 1/51 1/50
Non-Neoplastic Lesions	KIDNEY: INCREASED SEVERITY OF NEPHROPATHY

Male Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50
Non-Neoplastic Lesions	KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY BONE: FIBROUS OSTEODYSTROPHY GLANDULAR STOMACH: MINERALIZATION

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY BONE: FIBROUS OSTEODYSTROPHY GLANDULAR STOMACH: MINERALIZATION