Target Organs and Levels of Evidence for TR-427
Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CASRN 8024-37-1) (Major Component 79% Curcumin, CASRN 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Turmeric, oleoresin (curcumin)
8024-37-1 |
06/23/1992 |
Dosed-Feed
R & M: 0, .2, 1.0, AND 5.0% |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- FORESTOMACH: ULCER; HYPERPLASIA; HYPERKERATOSIS
- INTESTINES: ULCER; HYPERPLASIA; INFLAMMATION
- LYMPH NODE: (MESENTERIC) SINUS ECTASIA
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Clitoral Gland: ADENOMA 5/50 12/48 15/47 16/49 OR CARCINOMA 1/50 4/48 0/47 0/49 COMBINED 6/50 16/48 15/47 16/49
|
| Non-Neoplastic Lesions |
- INTESTINES: ULCER; HYPERPLASIA; INFLAMMATION
- LYMPH NODE: (MESENTERIC) SINUS ECTASIA
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 25/50 28/50 35/50 30/50 OR CARCINOMA 12/50 18/50 16/50 18/50 COMBINED 30/50 38/50 41/50 37/50
- Intestines: CARCINOMA 0/50 3/50 3/50 0/50
|
Female Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 7/50 8/50 19/51 14/50 OR CARCINOMA 7/50 5/50 10/51 6/50 COMBINED 13/50 12/50 25/51 19/50
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
