https://ntp.niehs.nih.gov/go/LOE-TR-428

Manganese sulfate monohydrate: Target Organs and Levels of Evidence for TR-428

Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Manganese sulfate monohydrate
10034-96-5		 06/23/1992 Dosed-Feed
R & M: 0, 1500, 5000, AND 15000 PPM/50 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
 
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 0/49 0/51 3/50
Non-Neoplastic Lesions
  • FORESTOMACH: FOCAL HYPERPLASIA; ULCER; INFLAMMATION
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 2/50 1/50 0/49 5/51
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • FORESTOMACH: FOCAL HYPERPLASIA