Manganese sulfate monohydrate: Target Organs and Levels of Evidence for TR-428
Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
Manganese sulfate monohydrate
10034-96-5 | 06/23/1992 | Dosed-Feed
R & M: 0, 1500, 5000, AND 15000 PPM/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: No Evidence
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Thyroid Gland Follicular Cell: ADENOMA 0/50 0/49 0/51 3/50
|
| Non-Neoplastic Lesions | - FORESTOMACH: FOCAL HYPERPLASIA; ULCER; INFLAMMATION
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
Female Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
| Neoplastic Lesions | - Thyroid Gland Follicular Cell: ADENOMA 2/50 1/50 0/49 5/51
|
| Non-Neoplastic Lesions | - THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- FORESTOMACH: FOCAL HYPERPLASIA
|
