Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9537

Manganese sulfate monohydrate: Target Organs and Levels of Evidence for TR-428

Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Manganese sulfate monohydrate
10034-96-5
06/23/1992 Dosed-Feed
R & M: 0, 1500, 5000, AND 15000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence

Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 0/49 0/51 3/50
Non-Neoplastic Lesions
  • FORESTOMACH: FOCAL HYPERPLASIA; ULCER; INFLAMMATION
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 2/50 1/50 0/49 5/51
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • FORESTOMACH: FOCAL HYPERPLASIA