https://ntp.niehs.nih.gov/go/LOE-TR-429

Target Organs and Levels of Evidence for TR-429

Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diethyl phthalate
84-66-2		 11/17/1993 Topical Application
R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP		 Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS
Other Considerations
  • LIVER: FATTY DEGENERATION 26/50 8/50 4/51
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS
Other Considerations
  • LIVER: FATTY DEGENERATION 23/50 11/50 3/50
  • MAMMARY GLAND: FIBROADENOMA 21/51 12/50 7/50
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/50 11/50 9/50 12/50 OR CARCINOMA 4/50 4/50 6/50 7/50 COMBINED 9/50 14/50 14/50 18/50
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCI
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 12/51 14/50 10/50 OR CARCINOMA 4/50 5/51 6/50 3/50 COMBINED 7/50 16/51 19/50 12/50
 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diethyl phthalate/dimethyl phthalate
DIETH/DIMETH		 11/17/1993 Topical Application
100 UL (PROMOTOR) NEAT CHEMICAL ON UNINITIATED AND DMBA INITIATED SKIN		 Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence

 
Type Organ/Tissue (Lesion)
Note 1-YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE SWISS CD-1 MICE. THERE WAS NO EVIDENCE OF INITIATING OR PROMOTING ACTIVITY. MINOR DERMAL ACANTHOSIS WAS OBSERVED FOLLOWING 1 YEAR EXPOSURE TO DIETHYLPHTHALATE OR DIMETHYLPHTHALATE.