https://ntp.niehs.nih.gov/go/9544

Target Organs and Levels of Evidence for TR-432

Toxicology and Carcinogenesis Studies of Barium Chloride Dihydrate (CASRN 10326-27-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Barium chloride dihydrate
10326-27-9		   Dosed-Water
0,125,4000 PPM/10 PER GROUP		 SRI International

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Barium chloride dihydrate
10326-27-9		 06/22/1993 Dosed-Water
0,500,1200,2500 PPM		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 35/50 25/50 26/50 15/50
  • ADRENAL GLAND: PHEOCHROMOCYTOMA 11/49 9/50 10/49 6/50 MALIGNANT PHEOCHROMOCYTOMA 2/49 2/50 2/49 0/50 COMBINED 13/49 11/50 12/49 6/50
Female Rats: No Evidence
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
Other Considerations
  • LIVER: ADENOMA 24/51 20/50 15/48 8/50
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY