Target Organs and Levels of Evidence for TR-433
Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tricresyl phosphate 1330-78-5 |
06/22/1993 |
Dosed-Feed R: 0,75,150,300,600, M: 0,60,125,250 PPM/50 PER GROUP |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- ADRENAL GLAND: CYTOPLASMIC VACUOLIZATION
- OVARY: INTERSTITIAL HYPERPLASIA
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- ADRENAL: CEROID PIGMENTATION
- LIVER: CEROID PIGMENTATION; CLEAR CELL FOCI; FATTY CHANGE
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- ADRENAL: CEROID PIGMENTATION
|