4,4-Thiobis(6-tert-butyl-m-cresol): Target Organs and Levels of Evidence for TR-435
Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
4,4-Thiobis(6-tert-butyl-m-cresol)
96-69-5 | 06/22/1993 | Dosed-Feed
R: 0,.05,.1,.25, M: 0,.025,.05,.1 % | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; MIXED CELL FOCI
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; FATTY CHANGE; MIXED CELL FOCI
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
| Other Considerations | - MAMMARY GLAND: FIBROADENOMA, ADENOMA, OR CARCINOMA COMBINED 32/50 24/50 11/50 16/50
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Other Considerations | - LIVER: FATTY CHANGE 19/50 17/50 5/50 6/50; CLEAR CELL FOCI 6/50 5/50 2/50 0/50; ADENOMA OR CARCINOMA COMBINED 25/50 30/50 27/50 16/50
|
Female Mice: No Evidence
