Target Organs and Levels of Evidence for TR-435
Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
4,4-Thiobis(6-tert-butyl-m-cresol) 96-69-5 |
06/22/1993 |
Dosed-Feed R: 0,.05,.1,.25, M: 0,.025,.05,.1 % |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; MIXED CELL FOCI
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; FATTY CHANGE; MIXED CELL FOCI
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Other Considerations |
- MAMMARY GLAND: FIBROADENOMA, ADENOMA, OR CARCINOMA COMBINED 32/50 24/50 11/50 16/50
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Other Considerations |
- LIVER: FATTY CHANGE 19/50 17/50 5/50 6/50; CLEAR CELL FOCI 6/50 5/50 2/50 0/50; ADENOMA OR CARCINOMA COMBINED 25/50 30/50 27/50 16/50
|
Female Mice: No Evidence