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https://ntp.niehs.nih.gov/go/8650

tert-Butyl alcohol: Target Organs and Levels of Evidence for TR-436

Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DateRoute/Exposure LevelsStudy Laboratory
tert-Butyl alcohol
75-65-0
06/21/1994Dosed-Water
MALE RATS: 0, 1.25, 2.5, 5 MG/ML; FEMALE RATS: 0, 2.5, 5, 10 MG/ML; MICE 0, 5, 10, 20 MG/ML/60 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50
Non-Neoplastic Lesions
  • KIDNEY: MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 2/58 3/60 2/59 9/59
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA