Target Organs and Levels of Evidence for TR-436
Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
tert-Butyl alcohol
75-65-0 |
06/21/1994 |
Dosed-Water
MALE RATS: 0, 1.25, 2.5, 5 MG/ML; FEMALE RATS: 0, 2.5, 5, 10 MG/ML; MICE 0, 5, 10, 20 MG/ML/60 PER GROUP |
Southern Research Institute |
Levels of Evidence
Male Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50
|
| Non-Neoplastic Lesions |
- KIDNEY: MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- KIDNEY: TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
|
Male Mice: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland Follicular Cell: ADENOMA 2/58 3/60 2/59 9/59
|
| Non-Neoplastic Lesions |
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
|
