Target Organs and Levels of Evidence for TR-437
Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Hexachlorocyclopentadiene 77-47-4 |
06/22/1993 |
Inhalation R:0,.01,.05,.2PPM M:0,.01,.05,.2,.5PPM/50 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
- NASAL CAVITY: PIGMENTATION
- TRACHEA: PIGMENTATION
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LARYNX: SQUAMOUS METAPLASIA
- LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
- NASAL CAVITY: PIGMENTATION
- TRACHEA: PIGMENTATION
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: MUCOSAL PIGMENTATION
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
- TRACHEA: MUCOSAL PIGMENTATION
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: MUCOSAL PIGMENTATION
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
- TRACHEA: MUCOSAL PIGMENTATION
|