Hexachlorocyclopentadiene: Target Organs and Levels of Evidence for TR-437
Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)
Chemical (Study Title)
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|
Hexachlorocyclopentadiene
77-47-4 | 06/22/1993 | Chemical used in the manufacture of flame retardants, resins, and chlorinated cyclodiene pesticides. | Inhalation
R:0,.01,.05,.2PPM M:0,.01,.05,.2,.5PPM/50 PER GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
- NASAL CAVITY: PIGMENTATION
- TRACHEA: PIGMENTATION
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LARYNX: SQUAMOUS METAPLASIA
- LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
- NASAL CAVITY: PIGMENTATION
- TRACHEA: PIGMENTATION
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: MUCOSAL PIGMENTATION
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
- TRACHEA: MUCOSAL PIGMENTATION
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - LUNG: MUCOSAL PIGMENTATION
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
- TRACHEA: MUCOSAL PIGMENTATION
|
