https://ntp.niehs.nih.gov/go/8654

Target Organs and Levels of Evidence for TR-438

Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CASRN 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Benzethonium chloride
121-54-0		   Topical Application
0,1.56,25.0 MG/KG/10 PER GROUP		 Battelle Columbus Laboratory

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Benzethonium chloride
121-54-0		 06/21/1994 Topical Application
R&M: 0,0.15,0.5,1.5 MG/KG/50/GROUP		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; ULCER
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA