Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/8672

Acetonitrile: Target Organs and Levels of Evidence for TR-447

Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DateRoute/Exposure LevelsStudy Laboratory
Acetonitrile
75-05-8
06/21/1994Inhalation
R: 0, 100, 200, OR 400 PPM M: 0, 50, 100, OR 200 PPM ; 50/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/48 1/47 1/48 3/48 OR CARCINOMA 1/48 0/47 0/48 3/48 COMBINED 1/48 1/47 1/48 5/48
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA