Target Organs and Levels of Evidence for TR-447
Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Acetonitrile 75-05-8 |
06/21/1994 |
Inhalation R: 0, 100, 200, OR 400 PPM M: 0, 50, 100, OR 200 PPM ; 50/GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 0/48 1/47 1/48 3/48 OR CARCINOMA 1/48 0/47 0/48 3/48 COMBINED 1/48 1/47 1/48 5/48
|
Female Rats: No Evidence
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS HYPERPLASIA
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- FORESTOMACH: SQUAMOUS HYPERPLASIA
|