Target Organs and Levels of Evidence for TR-448
Toxicology and Carcinogenesis Studies of Isobutyl Nitrite (CASRN 542-56-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Isobutyl nitrite
542-56-3 |
11/29/1994 |
Inhalation
R&M: 0, 37, 75, OR 150 PPM |
IIT Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
|
| Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 27/46 2/46 1/46 1/46
|
Female Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
|
| Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/46 1/45 0/46 1/46
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53
|
| May Have Been Related |
- Thyroid Gland Follicular Cell: ADENOMA 1/50 0/50 0/50 5/53
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- SPLEEN: HEMOSIDERIN PIGMENTATION
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA
- NASAL CAVITY: SEROUS EXUDATE; OLFACTORY EPITHELIAL ATROPHY
|
