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Target Organs and Levels of Evidence for TR-449

Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Triethanolamine 102-71-6	10/30/1998	Topical Application MR: 0, 32, 63, OR 125; FR: 0, 63, 125, OR 250; MM: 0, 200, 630, OR 2000; FM: 0, 100, 300, OR 1000 MG/KG; 60/GROUP	Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Kidney Tubular Cell: ADENOMA 0/50 1/50 4/49 2/50, STEP SECTIONS 1/50 2/50 6/49 4/50
Non-Neoplastic Lesions	SKIN: ACANTHOSIS; INFLAMMATION; ULCER KIDNEY: INCREASED SEVERITY OF HYPERPLASIA

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	SKIN: ACANTHOSIS; EPIDERMAL EROSION; INFLAMMATION; ULCER

Target Organs and Levels of Evidence for TR-449

Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Levels of Evidence

Male Rats: Equivocal Evidence

Female Rats: No Evidence

Male Mice: Inadequate Study

Female Mice: Inadequate Study