Tetrafluoroethylene: Target Organs and Levels of Evidence for TR-450
Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetrafluoroethylene 116-14-3 |
|
Inhalation 0,312,625,1250,2500,5000 PPM/010 PER GROUP |
Battelle Northwest Laboratory |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Tetrafluoroethylene 116-14-3 |
12/05/1995 |
Inhalation MICE & FR: 0, 312, 625, OR 1250 MR: 0, 156, 312, OR 625 PPM; 50/GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50
- Liver: ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50
|
May Have Been Related |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50
- Testis: INTERSTITIAL CELL ADENOMA 39/50 40/50 48/50 47/50
|
Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; TUBULE DEGENERATION; TUBULE HYPERPLASIA
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50
- Liver: ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50
- Vascular System (Liver): HEMANGIOSARCOMA 0/50 0/50 5/50 1/50
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULE DEGENERATION; TUBULE HYPERPLASIA
- LIVER: ANGIECTASIS
- EYE: CATARACTS
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48
- Hematopoietic System: HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48
- Vascular System (Liver): HEMANGIOMA 0/48 10/48 5/48 2/48 OR HEMANGIOSARCOMA 0/48 21/48 27/48 37/48 COMBINED 0/48 26/48 30/48 38/48
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULE DILATATION; TUBULE KARYOMEGALY
- LIVER: ANGIECTASIS
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47
- Hematopoietic System: HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48
- Vascular System (Liver): HEMANGIOMA 0/48 5/48 2/47 1/47 OR HEMANGIOSARCOMA 0/48 27/48 27/47 34/47 COMBINED 0/48 31/48 28/47 35/47
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULE KARYOMEGALY
- LIVER: ANGIECTASIS; HEMATOPOIETIC CELL PROLIFERATION
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|