Target Organs and Levels of Evidence for TR-453
Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Nickel subsulfide 12035-72-2 |
11/29/1994 |
Inhalation R: 0, 0.075, OR 0.15 M: 0, 0.6, OR 1.2 MG/M3; 50/GROUP |
Lovelace Biomedical & Environmental Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/53 30/52 38/53 OR MALIGNANT PHEOCHROMOCYTOMA 0/53 2/52 10/53 COMBINED 14/53 30/52 38/53
|
Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS
- NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/53 7/53 36/53
|
Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS
- NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
- ADRENAL GLAND: (MEDULLA) HYPERPLASIA
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS
- NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS
- NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
|