https://ntp.niehs.nih.gov/go/8686

Target Organs and Levels of Evidence for TR-454

Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Nickel sulfate hexahydrate
10101-97-0		 11/29/1994 Inhalation
R: 0, 0.125, 0.25, OR 0.5 M: 0, .25, .5, OR 1.0 MG/M3; 50/GROUP		 Lovelace Biomedical & Environmental Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY