Target Organs and Levels of Evidence for TR-454
Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Nickel sulfate hexahydrate
10101-97-0 |
11/29/1994 |
Inhalation
R: 0, 0.125, 0.25, OR 0.5 M: 0, .25, .5, OR 1.0 MG/M3; 50/GROUP |
Lovelace Biomedical & Environmental Research Institute |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
- LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
- NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
- LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
- NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
- LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
- NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
- LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
- NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
|
