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Codeine: Target Organs and Levels of Evidence for TR-455

Toxicology and Carcinogenesis Studies of Codeine (CASRN 76-57-3) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Codeine
76-57-3
Dosed-Feed
0,390,6250 PPM/10 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence: None



Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Codeine
76-57-3
06/20/1995 Dosed-Feed
R: 0, 400, 800, OR 1600 M: 0, 750, 1500, OR 3000 PPM; 60/GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Other Considerations
  • ADRENAL MEDULLA: PHEOCHROMOCYTOMA 16/49 6/50 6/50 3/50
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 27/50 21/50 27/51 8/51 OR ADENOCARCINOMA 3/50 2/50 3/51 0/51 COMBINED 30/50 23/50 29/51 8/51
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA