https://ntp.niehs.nih.gov/go/8690

1,2-Dihydro-2,2,4-trimethylquinoline (monomer): Target Organs and Levels of Evidence for TR-456

Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1,2-Dihydro-2,2,4-trimethylquinoline (monomer)
147-47-7		 06/20/1995 Topical Application
RATS: 0, 36, 60, OR 100 MG/KG MICE: 0, 3.6, 6.0, OR 10.0 MG/KG		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Type Organ/Tissue (Lesion)
Note
  • 1 YEAR DERMAL INITIATION/PROMOTION STUDY IN FEMALE SENCAR MICE. THERE WAS NO EVIDENCE OF INITIATING OR PROMOTING ACTIVITY.
 
Chemical (Study Title)
CASRN		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
1,2-Dihydro-2,2,4-trimethylquinoline (monomer)
147-47-7		 06/20/1995 Monomer polymerized for use as a rubber and latex antioxidant. Topical Application
RATS: 0, 60, OR 100 MG/KG MICE: 0, 6, OR 10 MG/KG (CORE)		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA (SINGLE SECTIONS) 1/50 7/50 10/50 7/50 (STEP SECTIONS) 6/50 5/50 6/50 8/50 (COMBINED) 7/50 11/50 14/50 14/50; CARCINOMA (SINGLE SECTIONS) 0/50 1/50 0/50 0/50 (STEP SECTIONS) 0/50 1/50 0/50 0/50 (COMBINED) 0/50 1/50 0/50 0/50; ADENOMA OR CARCINOMA COMBINED (SINGLE SECTIONS) 1/50 8/50 10/50 7/50 (STEP SECTIONS) 6/50 6/50 6/50 8/50 (COMBINED) 7/50 12/50 14/50 14/50
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS; HYPERKERATOSIS
Male Mice: No Evidence
Female Mice: No Evidence