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https://ntp.niehs.nih.gov/go/8694

Butyl benzyl phthalate: Target Organs and Levels of Evidence for TR-458

Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Butyl benzyl phthalate
85-68-7
Dosed-Feed
0,.16,2.5 %/10 PER GROUP
Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence: None



Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Butyl benzyl phthalate
85-68-7
06/20/1995 Plasticizer for PVC-based flooring products. Also used in biodegradable tampon ejectors, organic intermediate. A plasticizer for vinyl chloride plastics. A plasticizer added to polymers to give flexibility and softness. It is used extensively in polyvinyl chloride and in cellulose plastics, polyvinyl acetate, polysulfides, and polyurethane. Dosed-Feed
MR: 0, .3%, .6%, OR 1.2%; 60/GROUP FR: 0, .6%, 1.2%, OR 2.4%; 60/GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 3/50 2/49 3/50 10/50 OR CARCINOMA 0/50 0/49 0/50 1/50 COMBINED 3/50 2/49 3/50 11/50
Non-Neoplastic Lesions
  • PANCREAS: FOCAL HYPERPLASIA
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 0/50 0/50 0/50 2/50
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 1/50 0/50 0/50 2/50
Non-Neoplastic Lesions
  • URINARY BLADDER: TRANSITIONAL EPITHELIAL HYPERPLASIA