Target Organs and Levels of Evidence for TR-465
Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Phenolphthalein 77-09-8 |
|
Dosed-Feed 0,.3,5 %/5 PER GROUP |
BioReliance, Inc |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Phenolphthalein 77-09-8 |
12/05/1995 |
Dosed-Feed R: 0, 1.2, 2.5, OR 5%; M: 0, 0.3, 0.6, OR 1.2% IN FEED (50/SEX/SPECIES/GROUP) |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50
|
Non-Neoplastic Lesions |
- ADRENAL GLAND: MEDULLA, FOCAL HYPERPLASIA
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Adrenal Gland Medulla: PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49
|
Non-Neoplastic Lesions |
- KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49
|
Non-Neoplastic Lesions |
- THYMUS: ATYPICAL HYPERPLASIA
- TESTIS: GERMINAL EPITHELIAL DEGENERATION
|
Other Considerations |
- LIVER: ADENOMA 22/50 12/50 8/50 10/49 OR CARCINOMA 8/50 10/50 5/50 9/49 COMBINED 27/50 20/50 11/50 16/49; CLEAR CELL FOCUS 24/50 6/50 1/50 0/49; EOSINOPHILIC FOCUS 22/50 6/50 1/50 1/49; MIXED CELL FOCUS 6/50 2/50 1/50 0/49
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Hematopoietic System: HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50
- Ovary: BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50
|
Non-Neoplastic Lesions |
- THYMUS: ATYPICAL HYPERPLASIA
- OVARY: HYPERPLASIA
|
Other Considerations |
- LIVER: ADENOMA 17/50 2/50 6/50 1/50 OR CARCINOMA 6/50 1/50 0/50 1/50 COMBINED 21/50 3/50 6/50 2/50; EOSINOPHILIC FOCUS 20/50 4/50 2/50 1/50
|