Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6241

Phenolphthalein: Target Organs and Levels of Evidence for TR-465

Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Phenolphthalein
77-09-8		 Dosed-Feed
0,.3,5 %/5 PER GROUP		 BioReliance, Inc

Levels of Evidence: None



Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Phenolphthalein
77-09-8		 12/05/1995 Dosed-Feed
R: 0, 1.2, 2.5, OR 5%; M: 0, 0.3, 0.6, OR 1.2% IN FEED (50/SEX/SPECIES/GROUP)		 T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50
Non-Neoplastic Lesions
  • ADRENAL GLAND: MEDULLA, FOCAL HYPERPLASIA
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49
Non-Neoplastic Lesions
  • KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49
Non-Neoplastic Lesions
  • THYMUS: ATYPICAL HYPERPLASIA
  • TESTIS: GERMINAL EPITHELIAL DEGENERATION
Other Considerations
  • LIVER: ADENOMA 22/50 12/50 8/50 10/49 OR CARCINOMA 8/50 10/50 5/50 9/49 COMBINED 27/50 20/50 11/50 16/49; CLEAR CELL FOCUS 24/50 6/50 1/50 0/49; EOSINOPHILIC FOCUS 22/50 6/50 1/50 1/49; MIXED CELL FOCUS 6/50 2/50 1/50 0/49
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50
  • Ovary: BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50
Non-Neoplastic Lesions
  • THYMUS: ATYPICAL HYPERPLASIA
  • OVARY: HYPERPLASIA
Other Considerations
  • LIVER: ADENOMA 17/50 2/50 6/50 1/50 OR CARCINOMA 6/50 1/50 0/50 1/50 COMBINED 21/50 3/50 6/50 2/50; EOSINOPHILIC FOCUS 20/50 4/50 2/50 1/50