Target Organs and Levels of Evidence for TR-466
Toxicology and Carcinogenesis Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Ethylbenzene
100-41-4 |
12/11/1996 |
Inhalation
R&M: 0, 75, 250, OR 750 PPM (50/SEX/SPECIES/GROUP) |
IIT Research Institute |
Levels of Evidence
Male Rats: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50
- Testis: ADENOMA 36/50 33/50 40/50 44/50
|
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA
|
Female Rats: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49
|
| Non-Neoplastic Lesions |
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA
|
Male Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50
|
| Non-Neoplastic Lesions |
- LUNG: ALVEOLAR EPITHELIAL METAPLASIA
- LIVER: SYNCYTIAL ALTERATION; HYPERTROPHY; NECROSIS
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50
|
| Non-Neoplastic Lesions |
- LIVER: EOSINOPHILIC FOCUS
- PITUITARY GLAND: HYPERPLASIA
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
