Target Organs and Levels of Evidence for TR-469
Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 |
12/11/1996 | Gavage MICE ONLY: 0, 30, 60, OR 120 MG/KG; 50/SEX |
Southern Research Institute |
Levels of Evidence
Male Mice: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Interferon AD (AIDS Initiative) INTERFERONAD |
12/11/1996 | Subcutaneous Injection MICE ONLY: 500 OR 5000 UNITS 3X/WEEK; 50/SEX/GROUP |
Southern Research Institute |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) INTAZTCOMB |
12/11/1996 | Subcutaneous Injection and Gavage DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK |
Southern Research Institute |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Interferon A (AIDS Initiative) 76543-88-9 |
12/11/1996 | Subcutaneous Injection 5000 UNITS 3X A WEEK; 50/SEX/GROUP |
Southern Research Institute |