Target Organs and Levels of Evidence for TR-470
Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Pyridine 110-86-1 |
12/10/1997 |
Dosed-Water R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP) |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49 (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; PERIPORTAL FIBROSIS; FIBROSIS; CENTRILOBULAR DEGENERATION OR NECROSIS; PIGMENTATION
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 12/50 16/50 22/50 23/50
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; CENTRILOBULAR DEGENERATION; BILE DUCT HYPERPLASIA; PIGMENTATION
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 29/50 40/50 34/49 39/50 CARCINOMA 15/50 35/50 41/49 40/50 HEPATOBLASTOMA 2/50 18/50 22/49 15/50 COMBINED 38/50, 47/50, 46/49, 47/50
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 37/49 39/50 43/50 34/50 CARCINOMA 13/49 23/50 33/50 41/50 HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50
|
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Pyridine 110-86-1 |
12/10/1997 |
Dosed-Water |
T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Testis: INTERSTITIAL CELL ADEMONA 5/50 6/49 4/49 12/50
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR DEGENERATION AND NECROSIS; FIBROSIS; PERIPORTAL FIBROSIS; PIGMENTATION
- GLANDULAR STOMACH: MINERALIZATION
- PARATHYROID GLAND: HYPERPLASIA
|