Skip to Main Navigation
Skip to Page Content
COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6251

Target Organs and Levels of Evidence for TR-470

Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Pyridine
110-86-1
12/10/1997 Dosed-Water
R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP)
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49 (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; PERIPORTAL FIBROSIS; FIBROSIS; CENTRILOBULAR DEGENERATION OR NECROSIS; PIGMENTATION
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 12/50 16/50 22/50 23/50
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; CENTRILOBULAR DEGENERATION; BILE DUCT HYPERPLASIA; PIGMENTATION
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 29/50 40/50 34/49 39/50 CARCINOMA 15/50 35/50 41/49 40/50 HEPATOBLASTOMA 2/50 18/50 22/49 15/50 COMBINED 38/50, 47/50, 46/49, 47/50
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 37/49 39/50 43/50 34/50 CARCINOMA 13/49 23/50 33/50 41/50 HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50


Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Pyridine
110-86-1
12/10/1997 Dosed-Water T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Testis: INTERSTITIAL CELL ADEMONA 5/50 6/49 4/49 12/50
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR DEGENERATION AND NECROSIS; FIBROSIS; PERIPORTAL FIBROSIS; PIGMENTATION
    • GLANDULAR STOMACH: MINERALIZATION
    • PARATHYROID GLAND: HYPERPLASIA