Pyridine: Target Organs and Levels of Evidence for TR-470
Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Pyridine 110-86-1 | 12/10/1997 | Dosed-Water R: 0, 100, 200, OR 400 PPM MM: 0, 250, 500, OR 1000 PPM FM: 125, 250, OR 500 PPM MWR: 0, 100, 200, OR 400 PPM (50/SEX/GROUP) | T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Kidney Tubular Cell:
(SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49 (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49
|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; PERIPORTAL FIBROSIS; FIBROSIS; CENTRILOBULAR DEGENERATION OR NECROSIS; PIGMENTATION
|
Female Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
May Have Been Related | - Hematopoietic System:
MONONUCLEAR CELL LEUKEMIA 12/50 16/50 22/50 23/50
|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR CYTOMEGALY; CYTOPLASMIC VACUOLIZATION; CENTRILOBULAR DEGENERATION; BILE DUCT HYPERPLASIA; PIGMENTATION
|
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
ADENOMA 29/50 40/50 34/49 39/50 CARCINOMA 15/50 35/50 41/49 40/50 HEPATOBLASTOMA 2/50 18/50 22/49 15/50 COMBINED 38/50, 47/50, 46/49, 47/50
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
ADENOMA 37/49 39/50 43/50 34/50 CARCINOMA 13/49 23/50 33/50 41/50 HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50
|
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Pyridine 110-86-1 | 12/10/1997 | Dosed-Water
| T.S.I. Mason Laboratories, Inc. |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Testis:
INTERSTITIAL CELL ADEMONA 5/50 6/49 4/49 12/50
|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR DEGENERATION AND NECROSIS; FIBROSIS; PERIPORTAL FIBROSIS; PIGMENTATION
- GLANDULAR STOMACH: MINERALIZATION
- PARATHYROID GLAND: HYPERPLASIA
|