https://ntp.niehs.nih.gov/go/6255

Target Organs and Levels of Evidence for TR-472

Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Isobutyraldehyde
78-84-2		   Inhalation
0,500,8000 PPM/10 PER GROUP		 Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Isobutyraldehyde
78-84-2		 12/12/1996 Inhalation
R&M: 0, 500, 1000, OR 2000 PPM (50/SEX/SPECIES/GROUP)		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; OLFACTORY EPITHELIUM DEGENERATION; SUPPURATIVE INFLAMMATION
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; OLFACTORY EPITHELIUM DEGENERATION; SUPPURATIVE INFLAMMATION
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM DEGENERATION
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM DEGENERATION