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https://ntp.niehs.nih.gov/go/6257

Theophylline: Target Organs and Levels of Evidence for TR-473

Toxicology and Carcinogenesis Studies of Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Theophylline
58-55-9
Dosed-Feed
0,1000,2000,4000 PPM
Southern Research Institute

Levels of Evidence: None



Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Theophylline
58-55-9
Gavage
R: 0,37.5,75,150, M: 0,75,150,300 MG/KG
Southern Research Institute

Levels of Evidence: None



Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Theophylline
58-55-9
12/11/1996 Gavage
R: 7.5, 25, OR 75 MG/KG; 50/GROUP FM: 7.5, 25, OR 75 MG/KG; 50/GROUP MM: 15, 50, OR 150 MG/KG; 50/GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Mesenteric Artery: Chronic inflammation
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Decreased Incidences
  • Mammary Gland: Fibroadenoma, fibroadenoma or carcinoma
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Decreased Incidences
  • Liver: hepatocellular adenoma, hepatocellular carcinoma, hepatocellular adenoma or carcinoma
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Decreased Incidences
  • Liver: hepatocellular adenoma, hepatocellular carcinoma, hepatocellular adenoma or carcinoma