Target Organs and Levels of Evidence for TR-476
Toxicology and Carcinogenesis Studies of Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|---|---|---|
Primidone (primaclone) 125-33-7 |
12/12/1996 | Dosed-Feed M: 0, 0.03, 0.06, OR 0.13% R: 0, 0.06, 0.13, OR 0.25% (50/SEX/SPECIES) |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Non-Neoplastic Lesions |
|
Male Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|---|
Neoplastic Lesions |
|
Non-Neoplastic Lesions |
|