Target Organs and Levels of Evidence for TR-478
Toxicology and Carcinogenesis Studies of Diethanolamine (CASRN 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Diethanolamine
111-42-2 |
12/10/1997 |
Topical Application
MR: 0, 16, 32, OR 64 MG/KG; FR: 0, 8, 16, OR 32 MG/KG; MICE: 0, 40, 80, OR 160 MG/KG (50/SEX/SPECIES/GROUP) |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SKIN: ACANTHOSIS; HYPERKERATOSIS
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SKIN: HYPERKERATOSIS
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Male Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50
|
| Non-Neoplastic Lesions |
- LIVER: CYTOPLASMIC ALTERATION; SYNCYTIAL ALTERATION
- KIDNEY: TUBULE HYPERPLASIA
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- SKIN: HYPERKERATOSIS
|
Female Mice: Clear Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50
|
| Non-Neoplastic Lesions |
- LIVER: SYNCYTIAL ALTERATION
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- SKIN: HYPERKERATOSIS
|
