Coconut oil acid diethanolamine condensate: Target Organs and Levels of Evidence for TR-479
Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Coconut oil acid diethanolamine condensate
68603-42-9 | 12/10/1997 | Topical Application
R: 0, 50, or 100 mg/kg M: 0, 100, or 200 mg/kg (50 sex/species/group) | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - Skin: epidermal hyperplasia; sebaceous gland hyperplasia; parakeratosis; hyperkeratosis
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Kidney Tubular Cell: adenoma or carcinoma (standard evaluation 0/50, 2/50, 0/50; standard and extended evaluations combined 0/50, 4/50, 1/50)
|
| Non-Neoplastic Lesions | - Skin: epidermal hyperplasia; sebaceous gland hyperplasia; parakeratosis; hyperkeratosis
- Forestomach: chronic active inflammation; epithelial hyperplasia; epithelial ulcer
|
| - Kidney: severity of nephropathy
|
Male Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver: adenoma 22/50, 35/50, 45/50; hepatoblastoma 1/50, 1/50, 10/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 29/50, 39/50, 49/50
- Kidney Tubular Cell: adenoma 1/50, 1/50, 7/50; renal tubule adenoma or carcinoma 1/50, 1/50, 9/50
|
| Non-Neoplastic Lesions | - Liver: eosinophilic foci
- Skin: epidermal hyperplasia; sebaceous gland hyperplasia; hyperkeratosis; ulcer
- Thyroid gland: follicular cell hyperplasia
|
Female Mice: Clear Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Liver: adenoma 32/50, 44/50, 43/50; hepatocellular carcinoma 3/50, 21/50, 32/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 33/50, 46/50, 48/50
|
| Non-Neoplastic Lesions | - Skin: epidermal hyperplasia; sebaceous gland hyperplasia; hyperkeratosis; chronic active inflammation; parakeratosis
- Thyroid gland: follicular cell hyperplasia
|
