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Target Organs and Levels of Evidence for TR-480

Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CASRN 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Lauric acid diethanolamine condensate
120-40-1		 12/10/1997 Topical Application
R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP)		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 23/50 32/49 29/50 ADENOMA OR CARCINOMA COMBINED 28/50 40/49 36/50
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS