Target Organs and Levels of Evidence for TR-480
Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CASRN 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Lauric acid diethanolamine condensate
120-40-1 |
12/10/1997 |
Topical Application
R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP) |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Liver: ADENOMA 23/50 32/49 29/50 ADENOMA OR CARCINOMA COMBINED 28/50 40/49 36/50
|
| Non-Neoplastic Lesions |
- SKIN: EPIDERMAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; HYPERKERATOSIS; CHRONIC INFLAMMATION; PARAKERATOSIS
|
