Skip to Main Navigation Skip to Page Content

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Target Organs and Levels of Evidence for TR-482

Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Furfuryl alcohol 98-00-0		Inhalation 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S)	Battelle Northwest Laboratory

Levels of Evidence: None

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Furfuryl alcohol 98-00-0	12/10/1997	Inhalation R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP)	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Nasal Cavity: ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50
Non-Neoplastic Lesions	NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA KIDNEY: INCREASED SEVERITY OF NEPHROPATHY

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Nasal Cavity: RESPIRATORY EPITHELIUM ADENOMA 0/49 0/50 0/48 1/49; LATERAL WALL ADENOMA 0/49 0/50 1/48 0/49 Kidney Tubular Cell: ADENOMA (SINGLE AND STEP SECTIONS) COMBINED 0/50 1/49 2/49 2/50
Non-Neoplastic Lesions	NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA KIDNEY: INCREASED SEVERITY OF NEPHROPATHY

Male Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50
Non-Neoplastic Lesions	NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA KIDNEY: INCREASED SEVERITY OF NEPHROPATHY

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA EYE: CORNEA DEGENERATION 3/49 1/49 4/49 26/50