Target Organs and Levels of Evidence for TR-482
Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Furfuryl alcohol 98-00-0 |
|
Inhalation 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S) |
Battelle Northwest Laboratory |
Levels of Evidence: None
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Furfuryl alcohol 98-00-0 |
12/10/1997 |
Inhalation R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP) |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Nasal Cavity: ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Nasal Cavity: RESPIRATORY EPITHELIUM ADENOMA 0/49 0/50 0/48 1/49; LATERAL WALL ADENOMA 0/49 0/50 1/48 0/49
- Kidney Tubular Cell: ADENOMA (SINGLE AND STEP SECTIONS) COMBINED 0/50 1/49 2/49 2/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Male Mice: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
- KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
- EYE: CORNEA DEGENERATION 3/49 1/49 4/49 26/50
|