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2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484

Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
2-Butoxyethanol (ethylene glycol monobutyl ether) 111-76-2	10/30/1998	Inhalation R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION LIVER: KUPFFER CELL PIGMENTATION

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
May Have Been Related	Adrenal Gland Medulla: BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 3/50 4/50 1/49 8/49
Non-Neoplastic Lesions	NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION LIVER: KUPFFER CELL PIGMENTATION

Male Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Vascular System (Liver): HEMANGIOSARCOMA 0/50 1/50 2/49 4/49
May Have Been Related	Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 1/50 2/49 2/49 Liver: HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49
Non-Neoplastic Lesions	FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION BONE MARROW: HYPERPLASIA LIVER: KUPFFER CELL PIGMENTATION

Female Mice: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 5/50 COMBINED 0/50 1/50 2/50 6/50
Non-Neoplastic Lesions	FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION LIVER: KUPFFER CELL PIGMENTATION