2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484
Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
2-Butoxyethanol (ethylene glycol monobutyl ether)
111-76-2 | 10/30/1998 | Inhalation
R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION
- LIVER: KUPFFER CELL PIGMENTATION
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Adrenal Gland Medulla:
BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 3/50 4/50 1/49 8/49
|
| Non-Neoplastic Lesions | - NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION
- LIVER: KUPFFER CELL PIGMENTATION
|
Male Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Vascular System (Liver):
HEMANGIOSARCOMA 0/50 1/50 2/49 4/49
|
| May Have Been Related | - Forestomach:
SQUAMOUS CELL PAPILLOMA 1/50 1/50 2/49 2/49
- Liver:
HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49
|
| Non-Neoplastic Lesions | - FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION
- BONE MARROW: HYPERPLASIA
- LIVER: KUPFFER CELL PIGMENTATION
|
Female Mice: Some Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Forestomach:
SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 5/50 COMBINED 0/50 1/50 2/50 6/50
|
| Non-Neoplastic Lesions | - FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION
- NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION
- LIVER: KUPFFER CELL PIGMENTATION
|
