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Target Organs and Levels of Evidence for TR-487

Toxicology and Carcinogenesis Studies of Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Isobutene
115-11-7		 12/10/1997 Inhalation
R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP)		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA 1/48 0/48 0/48 5/50
Non-Neoplastic Lesions
  • NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION