Target Organs and Levels of Evidence for TR-487
Toxicology and Carcinogenesis Studies of Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Isobutene 115-11-7 |
12/10/1997 |
Inhalation R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP) |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Thyroid Gland Follicular Cell: CARCINOMA 1/48 0/48 0/48 5/50
|
Non-Neoplastic Lesions |
- NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
|
Female Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
|
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
|