Isobutene: Target Organs and Levels of Evidence for TR-487
Toxicology and Carcinogenesis Studies of Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
---|
Isobutene 115-11-7 | 12/10/1997 | Inhalation R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Thyroid Gland Follicular Cell:
CARCINOMA 1/48 0/48 0/48 5/50
|
Non-Neoplastic Lesions | - NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION
|
Male Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
|
Female Mice: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION
|