Target Organs and Levels of Evidence for TR-490
Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Glutaraldehyde
111-30-8 |
10/30/1998 |
Inhalation
R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION;RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
|
Female Rats: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA
|
Female Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION; INFLAMMATION
|
