Glutaraldehyde: Target Organs and Levels of Evidence for TR-490
Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Glutaraldehyde
111-30-8 | 10/30/1998 | Inhalation
R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP | Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION;RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
|
Male Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION; INFLAMMATION
|
