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Target Organs and Levels of Evidence for TR-490

Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Glutaraldehyde
111-30-8		 10/30/1998 Inhalation
R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION;RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION; INFLAMMATION