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Target Organs and Levels of Evidence for TR-493

Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Emodin
518-82-1		 05/21/1999 Dosed-Feed
R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX		 Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL HYALINE DROPLET; TUBULAR CELL PIGMENTATION; INCREASED SEVERITY OF PIGMENTATION
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 31/50 29/50 18/50
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Zymbal Gland: CARCINOMA 0/50 0/50 0/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL HYALINE DROPLET; INCREASED SEVERITY OF PIGMENTATION
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 17/50 16/50 3/50
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Kidney Tubular Cell: ADENOMA (STANDARD) 0/49 1/50 1/50 0/50 (STANDARD AND EXTENDED) 0/49 1/50 1/50 1/50 OR CARCINOMA (STANDARD) 0/49 0/50 1/50 1/50 (STANDARD AND EXTENDED) 0/49 0/50 1/50 1/50 COMBINED (STANDARD) 0/49 1/50 2/50 1/50 (STANDARD AND EXTENDED) 0/49 1/50 2/50 2/50
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL PIGMENTATION
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL PIGMENTATION; INCERASED SEVERITY OF NEPHROPATHY