Target Organs and Levels of Evidence for TR-493
Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Emodin 518-82-1 |
05/21/1999 |
Dosed-Feed R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX |
Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: TUBULAR CELL HYALINE DROPLET; TUBULAR CELL PIGMENTATION; INCREASED SEVERITY OF PIGMENTATION
|
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 31/50 29/50 18/50
|
Female Rats: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Zymbal Gland: CARCINOMA 0/50 0/50 0/50 3/50
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULAR CELL HYALINE DROPLET; INCREASED SEVERITY OF PIGMENTATION
|
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 17/50 16/50 3/50
|
Male Mice: Equivocal Evidence
Type |
Organ/Tissue (Lesion) |
May Have Been Related |
- Kidney Tubular Cell: ADENOMA (STANDARD) 0/49 1/50 1/50 0/50 (STANDARD AND EXTENDED) 0/49 1/50 1/50 1/50 OR CARCINOMA (STANDARD) 0/49 0/50 1/50 1/50 (STANDARD AND EXTENDED) 0/49 0/50 1/50 1/50 COMBINED (STANDARD) 0/49 1/50 2/50 1/50 (STANDARD AND EXTENDED) 0/49 1/50 2/50 2/50
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULAR CELL PIGMENTATION
|
Female Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
- KIDNEY: TUBULAR CELL PIGMENTATION; INCERASED SEVERITY OF NEPHROPATHY
|