Emodin: Target Organs and Levels of Evidence for TR-493
Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
|---|
Emodin
518-82-1 | 05/21/1999 | Dosed-Feed
R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX | Southern Research Institute |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR CELL HYALINE DROPLET; TUBULAR CELL PIGMENTATION; INCREASED SEVERITY OF PIGMENTATION
|
| Other Considerations | - HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 31/50 29/50 18/50
|
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Zymbal Gland:
CARCINOMA 0/50 0/50 0/50 3/50
|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR CELL HYALINE DROPLET; INCREASED SEVERITY OF PIGMENTATION
|
| Other Considerations | - HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 17/50 16/50 3/50
|
Male Mice: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| May Have Been Related | - Kidney Tubular Cell:
ADENOMA (STANDARD) 0/49 1/50 1/50 0/50 (STANDARD AND EXTENDED) 0/49 1/50 1/50 1/50 OR CARCINOMA (STANDARD) 0/49 0/50 1/50 1/50 (STANDARD AND EXTENDED) 0/49 0/50 1/50 1/50 COMBINED (STANDARD) 0/49 1/50 2/50 1/50 (STANDARD AND EXTENDED) 0/49 1/50 2/50 2/50
|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR CELL PIGMENTATION
|
Female Mice: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: TUBULAR CELL PIGMENTATION; INCERASED SEVERITY OF NEPHROPATHY
|
