Target Organs and Levels of Evidence for TR-494
Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Anthraquinone 84-65-1 |
12/09/2004 |
Dosed-Feed R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM |
Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Some Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 1/50 3/50 9/50 5/50 3/50
- Kidney Transitional Cell: PAPILLOMA 0/50 0/50 2/50 0/50 1/50
- Urinary Bladder: TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49
|
May Have Been Related |
- Liver: ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50
|
Non-Neoplastic Lesions |
- KIDNEY: HYALINE DROPLET ACCUMULATION; INCREASED SEVERITY OF NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
- LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CYTOPLASMIC VACUOLIZATION
- SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
- BONE MARROW: HYPERPLASIA
|
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 25/50 2/50 1/50 5/50 7/50
|
Female Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49
- Urinary Bladder: TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49
- Liver: ADENOMA 0/50 2/50 6/50 4/50 3/50
|
Non-Neoplastic Lesions |
- KIDNEY: HYALINE DROPLET ACCUMULATION; NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TUBULAR CELL HYPERPLASIA; TRANSITIONAL EPITHELIAL HYPERPLASIA
- LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; ANGIECTASIS
- SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
- BONE MARROW: HYPERPLASIA; ATROPHY
|
Other Considerations |
- HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 18/50 1/50 1/50 2/50 0/50
|
Male Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49
|
May Have Been Related |
- Thyroid Gland Follicular Cell: ADENOMA 0/50 0/50 2/49 2/46
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; HEPATOCYTE ERYTHROPHAGOCYTOSIS; EOSINOPHILIC FOCUS; FOCAL NECROSIS
- URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
- THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
- KIDNEY: PIGMENTATION
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49
|
May Have Been Related |
- Thyroid Gland Follicular Cell: ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48
|
Non-Neoplastic Lesions |
- LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; EOSINOPHILIC FOCUS
- URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
- SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
|