Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14838

Sodium nitrite: Target Organs and Levels of Evidence for TR-495

Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Sodium nitrite
7632-00-0
05/18/2000 Dosed-Water
R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 17/50 12/50 7/50 3/50
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 15/50 10/50 1/50 1/50
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: EPITHELIAL HYPERPLASIA
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 1/50 5/50


Chemical (Study Title)
CASRN
Peer Review Date Route/Exposure Levels Study Laboratory
Sodium nitrite
7632-00-0
Dosed-Water
R&M: 375 - 5000 PPM/10 PER GROUP
BioReliance, Inc

Levels of Evidence: None