Target Organs and Levels of Evidence for TR-496
Toxicology and Carcinogenesis Studies of Fumonisin B1 (CASRN 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN |
Peer Review Date |
Route/Exposure Levels |
Study Laboratory |
Fumonisin B1 116355-83-0 |
05/21/1999 |
Dosed-Feed R&M: 0, 5, 15, 50, 100, OR 150 PPM |
National Center for Toxicological Research |
Levels of Evidence
Male Rats: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Kidney Tubular Cell: ADENOMA 0/48 0/40 0/48 2/48 5/48 OR CARCINOMA 0/48 0/40 0/48 7/48 10/48 COMBINED 0/48 0/40 0/48 9/48 15/48
|
Non-Neoplastic Lesions |
- KIDNEY: TUBULAR CELL EPITHELIAL HYPERPLASIA
|
Female Rats: No Evidence
Male Mice: No Evidence
Type |
Organ/Tissue (Lesion) |
Non-Neoplastic Lesions |
|
Female Mice: Clear Evidence
Type |
Organ/Tissue (Lesion) |
Neoplastic Lesions |
- Liver: ADENOMA 5/47 3/48 1/48 16/47 31/45 OR CARCINOMA 0/47 0/48 0/48 10/47 9/45 COMBINED 5/47 3/48 1/48 19/47 39/45
|
Non-Neoplastic Lesions |
- LIVER: HYPERTROPHY; APOPTOSIS
|