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Target Organs and Levels of Evidence for TR-496

Toxicology and Carcinogenesis Studies of Fumonisin B1 (CASRN 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Fumonisin B1
116355-83-0		 05/21/1999 Dosed-Feed
R&M: 0, 5, 15, 50, 100, OR 150 PPM		 National Center for Toxicological Research

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/48 0/40 0/48 2/48 5/48 OR CARCINOMA 0/48 0/40 0/48 7/48 10/48 COMBINED 0/48 0/40 0/48 9/48 15/48
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL EPITHELIAL HYPERPLASIA
Female Rats: No Evidence
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/47 3/48 1/48 16/47 31/45 OR CARCINOMA 0/47 0/48 0/48 10/47 9/45 COMBINED 5/47 3/48 1/48 19/47 39/45
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY; APOPTOSIS